|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Upregulation of Netrin-1 in the skin cells of a BRAFV600E-mutated murine model reduced cancer cell death and promoted melanoma progression.
|
31806640 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Deleted in Colorectal Cancer (DCC), the receptor for the multifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung metastasis by triggering cancer cell death when netrin-1 is lowly expressed.
|
31806640 |
2020 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Upregulation of Netrin-1 in the skin cells of a BRAFV600E-mutated murine model reduced cancer cell death and promoted melanoma progression.
|
31806640 |
2020 |
|
Arteriosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Netrin-1 plasma levels are lower in patients with subclinical atherosclerosis and in patients with arterial wall inflammation.
|
31801376 |
2020 |
|
Atherosclerosis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Netrin-1 plasma levels are lower in patients with subclinical atherosclerosis and in patients with arterial wall inflammation.
|
31801376 |
2020 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In vivo, aorta adventitial remodeling was accompanied with the down-regulation of netrin-1 in the perivascular sympathetic nerve in T2DM rats.
|
31846437 |
2020 |
|
Mental Depression
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in Netrin-1 and DCC are associated with depression, schizophrenia, and substance use.
|
31659271 |
2020 |
|
Depressive disorder
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in Netrin-1 and DCC are associated with depression, schizophrenia, and substance use.
|
31659271 |
2020 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together these data support that interfering with netrin-1 could be a viable therapeutic approach in patients with netrin-1-expressing melanoma.
|
31806640 |
2020 |
|
Depressed mood
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in Netrin-1 and DCC are associated with depression, schizophrenia, and substance use.
|
31659271 |
2020 |
|
Mental disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence.
|
31659271 |
2020 |
|
Chest Pain
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Approach and Results: Plasma Netrin-1 levels were measured in different patient cohorts: (1) 22 patients with high cardiovascular risk who underwent arterial wall inflammation assessment using positron-emission tomography / computed tomography, (2) 168 patients with a positive family history of premature atherosclerosis in whom coronary artery calcium scores were obtained, and (3) 104 patients with chest pain who underwent coronary computed tomography angiography imaging to evaluate plaque vulnerability and burden.
|
31801376 |
2020 |
|
Periodontal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Netrin-1 and its receptor Unc5b as markers of periodontal disease.
|
31769036 |
2020 |
|
Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Total amount of Netrin-1 in GCF was significantly higher in periodontitis than the others, and the levels were significantly reduced after NSPT.
|
31769036 |
2020 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Deleted in Colorectal Cancer (DCC), the receptor for the multifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung metastasis by triggering cancer cell death when netrin-1 is lowly expressed.
|
31806640 |
2020 |
|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The Netrin-1/DCC guidance system: dopamine pathway maturation and psychiatric disorders emerging in adolescence.
|
31659271 |
2020 |
|
Alcohol or Other Drugs use
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Now, a rapidly growing literature suggests that (1) these same alterations could occur in humans, and (2) genetic variants in Netrin-1 and DCC are associated with depression, schizophrenia, and substance use.
|
31659271 |
2020 |
|
Intestinal Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Deleted in Colorectal Cancer (DCC), the receptor for the multifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung metastasis by triggering cancer cell death when netrin-1 is lowly expressed.
|
31806640 |
2020 |
|
Cleft Lip with or without Cleft Palate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The functional variant of NTN1 contributes to the risk of nonsyndromic cleft lip with or without cleft palate.
|
31780810 |
2020 |
|
Periodontal inflammation
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of this study indicate that Netrin-1 and its receptor Unc5b may have essential roles in periodontal inflammation and those can be assumed as useful therapeutic agent to control inflammation and periodontal breakdown.
|
31769036 |
2020 |
|
Subarachnoid Hemorrhage
|
0.350 |
Biomarker
|
disease |
BEFREE |
The endovascular perforation SAH model was constructed using male C57BL/6J mice, and recombinant NTN-1 was administrated intravenously.
|
30614619 |
2019 |
|
Subarachnoid Hemorrhage
|
0.350 |
Biomarker
|
disease |
BEFREE |
This study was designed to discern the utility of serum netrin-1 as a biomarker for assessing the severity and prognosis of patients with aneurysmal SAH.
|
31047878 |
2019 |
|
Cleft upper lip
|
0.110 |
Biomarker
|
disease |
BEFREE |
NTN1 gene was risk to non-syndromic cleft lip only among Han Chinese population.
|
30506619 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SIGNIFICANCE: Netrin-1, a navigation cue during embryonic development, is upregulated in cancer-associated fibroblasts and regulates cancer cell stemness.
|
31088838 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, the objective of the present study was to investigate whether netrin‑1 regulates cancer cell migration and invasion under hypoxic conditions in lung cancer and explore the underlying mechanism.
|
30968155 |
2019 |